RAG-2 Unleashed: Lymphocytes Beware

RAG - I 1 and RAG - 2 , Adjacent Genes That Synergistically

The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected...

Chimeric IgH-TCR/ translocations in T lymphocytes mediated by RAG

Active shape models unleashed

Active Shape Models (ASMs) are a popular family of segmentation algorithms which combine local appearance models for boundary detection with a statistical shape model (SSM). They are especially popular in medical imaging due to their ability for fast and accurate segmentation of anatomical structures even in large and noisy 3D images. A well-known limitation of ASMs is that the shape constraint...

Haskell Type Constraints Unleashed

The popular Glasgow Haskell Compiler extends the Haskell 98 type system with several powerful features, leading to an expressive language of type terms. In contrast, constraints over types have received much less attention, creating an imbalance in the expressivity of the type system. In this paper, we rectify the imbalance, transferring familiar type-level constructs, synonyms and families, to...

Embedded BI: Agents Unleashed